Job Description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

About Eli Lilly’s Postdoctoral Scientist Program

When it comes to research and development, our goal is to discover and deliver innovative medicines that make life better for people around the world. It’s challenging, expensive and often filled with failure. But even when we fail, we advance medical science and understanding by learning more about diseases, biology and chemistry – ultimately bringing new solutions one step closer to reality. Over the course of our history, we have shed light on some of the toughest health care problems known to man – diabetes, heart disease, infectious diseases, neuroscience disorders, cancer and more. We could not pursue this without our research and development team. Postdoctoral scientists help us continue this pursuit. During your experience you will get:

Top industry research experience
Mentoring by some of Lilly’s top scientists
Laboratory and classroom training and education to further your development
Collaboration and networking across dozens of postdoctoral scientists and other researchers

Are you looking to make a significant difference by contributing to the understanding of the pharmacokinetics & pharmacodynamics of antibody-drug conjugates?

We are seeking an ambitious post-doctoral scientist with strong research and communication skills to contribute to high visible research projects. Your work will contribute to the development of physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) models for antibody-drug conjugates (ADCs). In this role, you will:

Contribute to the project research goals and deliverables
Develop deep understanding of physiochemical properties, disposition, and mechanism of action of ADC components (antibody, linker and payload) and intact ADCs
Establish mechanistic, comprehensive PBPK/PD models for ADCs and identify the key data needed to parameterize a useful PBPK/PD ADC model
Use models to predict the effect of intrinsic/extrinsic factors on antibody and payload exposure
Identify areas of key need across discovery and clinical development and champion creative solutions to address those needs
Maintain external awareness and learning to benefit the organization
Present findings at conferences and publish in high quality peer-reviewed journals
Working environment – primary mentors in small and large molecule PK/PD, collaboration with relevant functions across the organization

Basic Qualifications

PhD in Pharmaceutics, Computational Sciences, Engineering, or a related field

Additional Skills/Preferences

If you are described with these skills, you could be a great fit for the role:

Self-directed and highly motivated individual who wants to learn new techniques while continually pursuing research and publication goals
Excellent communicator (oral and written) with presentation experience, along with a strong publication record
Proficient in data analysis and reporting
Understanding of pharmacokinetics and/or pharmacodynamic principles
Experience in PBPK, QSP, PK/PD, exposure-response modeling or other modeling & simulation related subject area
Experience using relevant software such as Phoenix, NONMEM, R, SimCYP, Gastroplus, Monolix, Python, MATLAB, or similar

Additional Information

This position is not permanent. It is for a fixed duration of 2 years with potential to extend to 3 years. You will have opportunities to apply for full time positions after your duration is complete.