Job Description

In the race for the future of health – The Sanofi MRNA Center of Excellence (CoE)

At Sanofi, we believe in a world in which no one suffers or dies from vaccine-preventable diseases. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines for more people faster than before.

That’s why we’re looking for bold, optimistic world-changers to join the team at our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of 400 dedicated employees for it and using it as the foundation to implement integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.

Bring your ambition and optimism for the future to Sanofi. Join us

Senior Associate Scientist/Scientist – HT plasmid production

The Senior Associate Scientist/Scientist will be part of the High-Throughput Plasmid Production team carrying out different tasks to develop novel technologies as well as deliver high quality DNA templates for High-Throughput In-vitro Transcription work.

Key Responsibilities:

Responsible for carrying out and implementing new technology development within HT-DNA team

Bring expertise in novel pDNA scale up processes that can be used for high-throughput DNA template preparation

Assemble gene of interest into vector backbone via different molecular biology techniques – Gibson/Hi-Fi assembly, Golden Gate reaction, restriction enzyme based cloning

Design and implement new pDNA purification strategies for delivering high quality IVT template DNA for mRNA synthesis

Independently design and order primers, probes, gBlocks etc. Track, receive and manage the inventory as needed

Accurately follow protocols and reproduce consistent data to generate DNA templates for in-vitro transcription work

Generate high quality DNA template using plasmid and PCR workflow. Carry out optimization work related to different workflow

Provide accurate and reproducible data analytics for both plasmid DNA and PCR products

Experience with liquid handling system is a plus

Work with the high-throughput team members to manage, track and order lab supplies

Prepare technical reports, presentations, and recommendations to management and other stakeholders

Keep track of experiments in Benchling electronic notebook

The individual should be a collaborative team player with a strong work ethic and able to follow verbal instructions clearly

Ability to multi-task without making mistakes and finish the projects within given timeline

The individual should be able to function in a timeline driven, dynamic environment and be able to follow instructions in SOPs and adapt to the changes in protocols and projects quickly

This will be a lab-based position

Qualification:

BS or MS in Biotechnology, Molecular biology, biomedical engineering or related fields with more than 4 years of relevant industry or academic experience or PhD with less than one year postdoc experience

Experience with liquid handlers is preferred

Possess a deep understanding of molecular cloning techniques (restriction digestion based cloning, Gibson Assembly, Hi-Fi Assembly, In-Fusion cloning)

Hands-on experience with a range of molecular biology techniques - PCR, agarose gel electrophoresis, nucleic acid purification, sequencing etc. Experience working with magnetic bead based pDNA isolation and capillary electrophoresis will be a plus.

Experience in using molecular biology software such as Geneious is a must.

Must be well organized, self-motivated, proactive, work well under pressure and deadlines and detail oriented.

Ability to multi-task and coordinate work on several simultaneous projects

Ability to collaborate effectively both within and across teams. Must be a team player.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

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